Description
Key facts
CAS number:5108-96-3,
Form:SolidSee storage information,
Molecular weight:164.3 Da,
Molecular formula:C5H12N2S2,
PubChem:517348,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100 mM,
Biochemical name:Ammonium pyrrolidine-1-carbodithioate,
Biological description:Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.,
Canonical smiles:C1CCN(C1)C(=S)[S-].[NH4+],
InChi:InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3,
InChiKey:MDDIUTVUBYEEEM-UHFFFAOYSA-N,
IUPAC Name:azanium;pyrrolidine-1-carbodithioate
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ALDH1A1 also known as aldehyde dehydrogenase 1 family member A1 has a mass of approximately 54 kDa. This enzyme catalyzes the oxidation of aldehydes to carboxylic acids using NAD+ as a cofactor. ALDH1A1 plays an important role in retinoic acid biosynthesis which is important for cellular differentiation and development. This protein is expressed in a variety of tissues including the liver kidney and stem cells where it is an important marker for stem cell identification. ALDH1A1 is sometimes discussed in conjunction with 15-prostaglandin dehydrogenase (15-PGDH) due to their roles in cellular processes.
Biological function summary
ALDH1A1 participates in the detoxification of aldehydes protecting cells from oxidative stress. It is a part of the aldehyde dehydrogenase family which acts collectively to maintain cellular homeostasis. ALDH1A1 contributes to the metabolism of retinoids an essential process for stem cell differentiation and proliferation. Its activity in regulating retinoic acid levels impacts numerous biological processes supporting the conversion of vitamin A into active metabolites that affect cellular function.
Pathways
ALDH1A1 is an important player in the retinoic acid signaling pathway and the alcohol metabolism pathway. Its role in the retinoic acid signaling pathway influences gene expression involved in growth and development. ALDH1A1 works alongside retinol binding proteins and interacts with the CYP26 family of enzymes which are responsible for retinoic acid catabolism. In the alcohol metabolism pathway ALDH1A1 functions alongside alcohol dehydrogenase to process ethanol and other alcohols preventing the accumulation of toxic aldehydes.
ALDH1A1 has associations with various cancers and neurodegenerative diseases. The enzyme's role in detoxifying reactive aldehydes links it to protection against neurodegenerative disorders like Parkinson's disease where oxidative stress plays a part in neurodegeneration. In cancers ALDH1A1 functions as a cancer stem cell marker implicating it in carcinogenesis and tumor progression. The enzyme’s interaction with other proteins such as 15-PGDH further emphasizes its importance in disease contexts where inflammatory and oxidative stress pathways are involved.
