Description
Key facts
CAS number:136194-77-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:378.4 Da,
Molecular formula:C24H18N4O,
PubChem:3501,
Nature:Synthetic,
Biochemical name:Go-6976,
Biological description:Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.,
Canonical smiles:CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O,
InChi:InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29),
InChiKey:VWVYILCFSYNJHF-UHFFFAOYSA-N,
IUPAC Name:3-(23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-3-yl)propanenitrile
Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1711 Gö 6976. 1711-500 is the same size as the 500 µg size of ab141413.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Protein kinase C (PKC) is a family of enzymes playing important roles in cell signal transduction. This family includes PKC alpha PKC delta PKC mu/PKD PKC epsilon PKC beta 1 PKC beta 2 PKC gamma PKC eta and PLK4. PKC enzymes are serine/threonine kinases with a molecular mass ranging from approximately 77 to 94 kDa. They are expressed in various tissues like brain heart and lymphocytes. These kinases respond to increased diacylglycerol (DAG) and calcium levels to become active phosphorylating multiple target proteins to modulate cellular functions.
Biological function summary
Members of the PKC family mediate many cellular processes including cell growth differentiation and apoptosis. PKC alpha delta and epsilon for example are important in signal transduction pathways involved in immune response. These kinases can function independently or as part of larger protein complexes. PKC inhibitors help study the precise biological roles of these kinases by blocking their activity in cells.
Pathways
PKC family members participate in signaling pathways like the MAPK/ERK pathway and the PI3K/Akt pathway. These pathways are important for regulating cell proliferation and survival. PKC interacts with proteins such as Ras and Raf within these signaling cascades influencing the downstream signaling that affects cellular outcomes. The balance of PKC activity impacts not only normal cellular processes but also pathological conditions.
PKC family members are linked to conditions such as cancer and cardiovascular diseases. Abnormal PKC activity can lead to uncontrolled cell proliferation in cancers or altered cardiac functions in heart disease. Specifically PKC alpha and beta are associated with tumor progression whereas PKC epsilon has connections to cardiac hypertrophy. Understanding PKC's role in these diseases has led to the development of PKC inhibitors as potential therapeutic agents targeting these kinases to alter disease progression and outcomes.
