Description
Key facts
CAS number:485-63-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:270.24 Da,
Molecular formula:C15H10O5,
PubChem:5284648,
Nature:Synthetic,
Solubility:Soluble in DMSO,
Biochemical name:3',4',7-Trihydroxyisoflavone,
Biological description:Isoflavone. Inhibits PI3K, CDK, Cot and MKK4. Induces cell cycle arrest and suppresses proliferation.,
Canonical smiles:C1=CC(=C(C=C1C2=COC3=C(C2=O)C=CC(=C3)O)O)O,
InChi:InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H,
InChiKey:DDKGKOOLFLYZDL-UHFFFAOYSA-N,
IUPAC Name:3-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one
Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 1886 7,3',4'-Trihydroxyisoflavone. 1886-100 is the same size as the 100 mg size of ab141458.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Macrophage migration inhibitory factor (MIF) also known as glycosylation-inhibiting factor is a protein with a molecular mass of approximately 12.5 kDa. It plays a mechanistic role as a cytokine that regulates immune responses specifically influencing macrophage behavior. MIF expresses in various cell types including immune and epithelial cells. It gets secreted by activated lymphocytes and macrophages pointing to its involvement in the inflammatory process.
Biological function summary
MIF acts as an upstream regulator of innate immunity and exerts broad influence on cytokine release. MIF elevates pro-inflammatory cytokines like TNF-alpha and IL-1beta promoting an immune response. It does not typically form part of a complex but interacts with cell surface receptors like CD74 triggering intracellular signaling pathways. These interactions illustrate MIF as a regulator of immune cell recruitment and activation.
Pathways
MIF participates in the glucocorticoid receptor regulatory pathway and MAP kinase pathway. It shows interaction with JNK and ERK1/2 proteins which further map into important cellular reactions like stress response and cell proliferation. By integrating into these pathways MIF influences cell survival proliferation and inflammatory cascades emphasizing its role in immune regulation.
MIF links to inflammatory diseases such as rheumatoid arthritis and sepsis. It influences disease progression by interacting with proteins like TNF-alpha and IL-6 contributing to inflammatory damage. Elevated MIF levels often correlate with disease severity in rheumatoid arthritis acting as a potential target for therapy. Furthermore sepsis demonstrates a similar pattern where MIF modulation can impact patient outcomes underlining its relevance in clinical investigations.
