Description
Key facts
CAS number:458-37-7,
Purity:>98%,
Source:Curcuma longa,
Molecular weight:368.4 Da,
Molecular formula:C21H20O6,
PubChem:969516,
Nature:Native,
Solubility:Soluble in ethanol to 10 mMSoluble in DMSO to 10 mM,
Biochemical name:Curcumin,
Biological description:High purity flavonoid derivative. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Shows diverse range of actions including free radical scavenging activity, cardio and neuroprotective effects. Blood brain barrier permeable. Active in vitro and in vivo,
Canonical smiles:COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O,
Isomeric smiles:COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O,
InChi:InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+,
InChiKey:VFLDPWHFBUODDF-FCXRPNKRSA-N,
IUPAC Name:(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Amyloid Precursor Protein (APP) plays an important role in cellular physiology primarily known as the precursor to beta-amyloid (Aβ) peptides. APP sometimes called A4 or protease nexin-II weighs approximately 100-140 kDa. It is expressed in many tissues most prominently in the central nervous system. Tissue Factor also known as coagulation factor III is active in the blood coagulation cascade promoting thrombin generation and fibrin formation. Prostaglandin E1 is a lipid compound acting as a vasodilator and inhibitor of platelet aggregation. Monoamine Oxidase A (MAO-A) is an enzyme with a molecular mass around 60 kDa found in the liver and brain responsible for degrading neurotransmitters such as serotonin. MitoNEET a 2Fe–2S protein localized in the outer mitochondrial membrane engages in electron transport. HSD17B2 is an enzyme implicated in steroid metabolism mediating the conversion of active to inactive hormones.
Biological function summary
Each of these targets fulfills distinct functions critical for organismal regulation. APP undergoes cleavage by secretases forming amyloidogenic and non-amyloidogenic fragments which influence neural growth and repair. Tissue Factor begins the extrinsic pathway of the coagulation system forming a complex with Factor VIIa on the cell surface. Conversely Prostaglandin E1 a member of the eicosanoids group modulates inflammatory and vasodilatory responses. MAO-A is a mitochondrial enzyme catalyzing the oxidative deamination of neurotransmitters regulating mood and arousal while HSD17B2 modulates the hormonal regulation through steroid inactivation. MitoNEET helps manage redox reactions and iron-sulfur cluster transfer between the mitochondria and cytosol.
Pathways
APP connects to significant pathways like the amyloidogenic pathway which contributes to Aβ peptide formation and is linked with neurodegenerative processes. It interacts with secretases altering the balance between toxic and soluble peptides. The MAO-A pathway is part of catecholamine and serotonin metabolism important for synaptic transmission regulation linking to neurotransmitter-regulating proteins such as COMT. MitoNEET participates in electron transport interfacing with mitochondrial respiratory chain complexes. HSD17B2 functions in steroid metabolism pathways linking closely to hormones like estrogen and testosterone. Tissue Factor is integral to the coagulation cascade aligning with proteins such as Factor VII in initiating clot formation.
APP is definitively linked with Alzheimer's disease where its peptide derivative Aβ aggregates into plaques. This involves interactions with tau protein another Alzheimer's-associated target. Abnormal MAO-A activities correlate with psychiatric disorders like depression and anxiety influenced by altered serotonin and noradrenaline levels. Prostaglandin E1 is associated with inflammatory disorders utilized therapeutically in conditions like peripheral artery disease. Mutations in HSD17B2 gene can lead to hormonal disorders given its role in steroid inactivation. Tissue Factor expression is observed in various cancers contributing to metastasis and thrombosis involving interactions with thrombin pathways. MitoNEET dysregulation raises concerns in metabolic disorders such as diabetes due to its role in mitochondrial energy regulation.
