Description
Key facts
CAS number:689284-12-6,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:415.5 Da,
Molecular formula:C19H37N5O5,
PubChem:10093303,
Nature:Synthetic,
Solubility:Soluble in water to 50 mM,
Biochemical name:N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide,
Biological description:Broad spectrum inhibitor of TACE (TNF-α convertase/ADAM17/α-secretase), MMPs and other ADAMs. Blocks phorbol-12-myristate-13-acetate-induced (PMA) shedding of cell surface proteins such as TGF-α and β-amyloid precursor protein (IC50 = 10 μM). Inhibits TNF-α release.,
Canonical smiles:CC(C)CC(CC(=O)NO)C(=O)NC(C(=O)NC(C)C(=O)NCCN)C(C)(C)C,
Isomeric smiles:C[C@@H](C(=O)NCCN)NC(=O)[C@H](C(C)(C)C)NC(=O)C(CC(C)C)CC(=O)NO,
InChi:InChI=1S/C19H37N5O5/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25)/t12-,13?,15+/m0/s1,
InChiKey:LMIQCBIEAHJAMZ-RMTCENKZSA-N,
IUPAC Name:N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2069 TAPI-2. 2069-1 is the same size as the 1 mg size of ab142219.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions
