Description
Product details:
The Pneumocystis (Microorganism Stain) is intended for use in the histological visualization of
Pneumocystis carinii
in cytology smears, and paraffin or frozen tissue sections.
Other products for staining tissue sections
Find more kits and reagents in the
special stains guide
, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the
IHC kits and reagents guide
Staining Interpretation
Pneumocystis carinii
Violet/Purple
Connective Tissue
Blue/Green
Erythrocytes
Yellow
Rose/Purple
Cartilage
Rose/Purple
Control Tissue:
Any prepared slide that contains
Pneumocystis carinii.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pneumocystis carinii also known as Pneumocystis jirovecii is a fungal pathogen responsible for causing pneumonia particularly in immunocompromised individuals. This opportunistic microorganism is not characterized by a specific protein mass due to its complexity as an organism rather than a single target. Pneumocystis carinii is expressed in the lungs where it inhabits the alveolar spaces leading to respiratory infection. Staining methods such as the Pneumocystis stain and HIS-tag stain help visualize its presence in tissue samples aiding diagnosis and research.
Biological function summary
Pneumocystis carinii functions as a pathogen by forming cysts and trophic forms in the host's lung tissue. These forms interfere with gas exchange causing severe respiratory distress. Pneumocystis carinii does not belong to a complex; rather it initiates infection by adhering to alveolar epithelial cells. The organism's interaction with the host immune system triggers an inflammatory response which further complicates respiratory functions and can lead to life-threatening pulmonary compromise.
Pathways
Pneumocystis carinii primarily interacts with immune regulation pathways and the respiratory inflammation pathway. Upon infection components of the immune system such as T-cells and macrophages recognize the pathogen leading to an immune-mediated response. This activity can enhance host defense but often results in collateral lung tissue damage. Proteins like CD4 and CD8 T-lymphocytes play pivotal roles in these pathways responding to Pneumocystis carinii invasion by mediating immune responses.
Pneumocystis carinii is a well-established cause of Pneumocystis pneumonia (PCP) particularly in people with AIDS or those undergoing immunosuppressive therapy. PCP manifests as cough fever and progressive dyspnea. Additionally research suggests a possible connection between Pneumocystis infections and chronic obstructive pulmonary disease (COPD) exacerbations. CD4 T-cell depletion common in patients with HIV/AIDS exacerbates susceptibility to Pneumocystis carinii infection due to impaired immune response.
