Description
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q92794,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione
Product details:
This product was previously labelled as Histone acetyltransferase MYST3.
Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Histone acetyltransferase MYST3 also known as MOZ (Monocytic Leukemia Zinc Finger Protein) is an enzyme with acetyltransferase activity. It primarily acetylates histones influencing chromatin structure and gene expression. MYST3/MOZ has a molecular weight of approximately 270 kDa. Researchers observe its expression mainly in the nucleus where it plays important roles in transcriptional regulation. Apart from its activity on histones MYST3 also acts on non-histone proteins contributing to various cellular processes.
Biological function summary
This protein functions in regulating gene expression by modifying chromatin structure. It is a part of the large MYST family named for its founding members (MOZ YBF2/Sas3 Sas2 Tip60) which together form various multiprotein complexes. These complexes participate in critical biological processes like cell proliferation and differentiation. MYST3/MOZ acts as a transcriptional coactivator promoting acetylation that results in an open chromatin conformation conducive to transcription initiation.
Pathways
Acetyltransferases like MYST3/MOZ integrate into wider cellular signaling networks. Notably it plays a role in the transcription regulation pathway and the hematopoiesis pathway. These roles connect MYST3/MOZ to proteins such as RUNX1 a critical transcription factor in hematopoiesis. It's through these pathways that MYST3/MOZ influences cellular functioning and development demonstrating its importance in maintaining normal cellular activities.
Mutations or translocations involving MYST3/MOZ often associate with hematological malignancies notably acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The protein's interactions with RUNX1 in these disorders highlight its role in disrupting normal hematopoiesis. Understanding MYST3/MOZ's function and its role in disease progression can guide therapeutic development targeted at chromatin remodeling mechanisms in associated cancers.
