Product detailsWhat is this antibody validated in? Alexa Fluor® 488 Anti-CPT1A antibody [8F6AE9] (ab171449) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. Trusted by the scientific community Anti-CPT1A [8F6AE9] Alexa Fluor® 488 (ab171449) was first used in a scientific publication in 2013 and has been cited over 10 times in peer-reviewed journals. Related products Antibody clone 8F6AE9 is also available pre-conjugated to a variety of labels for your convenience – Anti-CPT1A Alexa Fluor® 488 [8F6AE9] (ab171449). Specificity confirmed The specificity of Alexa Fluor® 488 Anti-CPT1A antibody [8F6AE9] (ab171449) has been confirmed by Flow Cytometry testing in CPT1A Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [8F6AE9] also available for your convenience: ab128568, Alexa Fluor® 488 - ab171449, HRP - ab198494, Carrier free - ab300265
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or
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Supplementary informationThis supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CPT1A plays a vital role in energy production by facilitating mitochondrial fatty acid oxidation. It does not function as a solitary enzyme but often associates with other enzymes forming a multiprotein complex that includes acyl-CoA synthetase. This complex enables efficient fatty acid transport and oxidation converting stored fats into usable energy. As CPT1A primarily operates in the liver its activity significantly impacts overall lipid and energy homeostasis demonstrating its critical regulatory role.
Pathways
CPT1A is central to the fatty acid beta-oxidation pathway an important process for breaking down fatty acids to produce energy. This pathway also involves proteins such as CPT1B a related isoform present in muscle tissues. CPT1A's function is important in the liver's capacity to regulate energy balance and respond to metabolic demands. Additionally CPT1A interacts within the signaling pathway of AMPK (AMP-activated protein kinase) which further integrates it into broader metabolic regulation networks linking energy status to cellular function.
