Product detailsPatented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or
[email protected].
Supplementary informationThis supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These MHC molecules play a critical role in adaptive immunity. They form a complex with beta-2 microglobulin (β2m) to achieve stability and function properly on cell surfaces. HLA-A and HLA-B bind to short peptides derived from intracellular proteins which are then transported through the endoplasmic reticulum. The peptide-MHC complex is then expressed on the cell surface where it facilitates recognition by T cell receptors guiding immune responses against infected or transformed cells.
Pathways
MHC class I molecules are deeply involved in the antigen processing and presentation pathway as well as the immune effector process. In the antigen processing pathway proteins within the cell undergo degradation by the proteasome creating peptide fragments. These fragments are transported into the endoplasmic reticulum by the TAP (transporter associated with antigen processing) proteins where they bind with MHC class I forming a stable complex. Proteins like TAP and proteasome subunits work closely with MHC class I to ensure proper immune surveillance.
