Key facts
Target:MAP2See target data
Product details:
Mature Neuron Marker (MAP2, NeuN, NFH, PSD95, Synaptophysin) Antibody Sampler Panel ab218257 contains recombinant rabbit monoclonal antibodies against MAP2, NeuN, Neurofilament heavy polypeptide, PSD95, and Synaptophysin.
Since mature neurons are no longer able to divide their purpose focuses on receiving, processing, and transferring information in the central and peripheral nervous systems.
The antibodies in this panel were selected for their exceptional performance in IHC, alongside other applications. Please see the individual datasheets for additional information.
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email
[email protected].
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Synaptophysin Neurofilament heavy polypeptide (NF-H) PSD95 MAP2 and NeuN are essential proteins in neuronal tissues. Synaptophysin a glycoprotein with a mass of approximately 38 kDa is expressed mainly in presynaptic vesicles. Neurofilament heavy polypeptide or NF-H is a component of the neuronal cytoskeleton with a mass of about 200 kDa found throughout neurons. PSD95 also called DLG4 is an important scaffold protein in synaptic junctions. MAP2 known for its expression in dendrites is vital for microtubule stabilization. NeuN also called Fox-3 is a well-known marker for mature neurons with high expression in the nuclei of post-mitotic neurons.
Biological function summary
These proteins play important roles in neuronal development structure and function. Synaptophysin participates in synaptic vesicle cycling aiding neurotransmitter release. NF-H as part of the neurofilament complex contributes to axonal caliber and stability. PSD95 organizes protein complexes at postsynaptic sites facilitating synaptic signaling. MAP2 stabilizes microtubules essential for dendritic morphology and transport. NeuN marking indicates post-mitotic functionally mature neurons useful in identifying neuronal populations through immunohistochemistry.
Pathways
These proteins integrate into critical signaling cascades in the nervous system. Synaptophysin and PSD95 play roles in synaptic transmission pathways influencing neurotransmitter release and postsynaptic receptor clustering. NF-H and MAP2 fit into the cytoskeletal dynamics pathway affecting neuronal branching and plasticity. NeuN serves as a neuronal marker particularly highlighting neurons in mature neural circuits. Through these pathways PSD95 often interacts with NMDA receptors while Synaptophysin forms complexes with SNARE proteins.
Alterations in these proteins link to several neurological conditions. Synaptophysin changes associate with Alzheimer's disease where synaptic dysfunction occurs. NF-H accumulation relates to amyotrophic lateral sclerosis (ALS) contributing to axonal degeneration. In both cases proteins such as MAPT (tau) and TDP-43 interplay with these alterations. Synaptic and cytoskeletal dysfunction in these diseases underlines the importance of biomarkers like NeuN and MAP2 in clinical research and diagnostics.
