Description
Key facts
CAS number:1652591-81-5,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:510 Da,
Molecular formula:C27H32ClN5O3,
PubChem:86340151,
Nature:Synthetic,
Solubility:Soluble in DMSO to 50 mM,
Biochemical name:((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride,
Biological description:Potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC50 = 50 nM). Selective for PAD4 over PAD1-3. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is re-ordered to form a β-hairpin. It blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.,
Canonical smiles:CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl,
Isomeric smiles:CN1C2=C(C=C(C=C2OC)C(=O)N3CC[C@H]([C@H](C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl,
InChi:InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1,
InChiKey:MULKOGJHUZTANI-ADMBKAPUSA-N,
IUPAC Name:[(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylbenzimidazol-5-yl]methanone;hydrochloride
Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B1035 GSK-484 hydrochloride. B1035-500 is the same size as the 500 µg size of ab223598.
Protect from air and moisture.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions
