Description
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q640N1,
Animal free:No,
Carrier free:No,
Species:Mouse,
Storage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AE binding protein 1 also known as AEBP1 functions mechanically as a transcriptional repressor. It interacts with other proteins to alter gene expression. The protein has a molecular mass of approximately 150 kDa. Researchers find AEBP1 in various tissues but expression is high in adipose tissue and the uterus. The protein's role as a repressor links to its ability to modulate the activities of certain transcription factors influencing cellular processes.
Biological function summary
AEBP1 plays a role in regulating the expression of genes important for adipogenesis and inflammation. It acts as part of a transcriptional regulation complex that controls genes driving fat cell development and lipid metabolism. Beyond adipose tissue AEBP1 also influences inflammatory responses which may connect to its function in modulating the immune system. The protein's ability to interact with intracellular pathways points to its involvement in cellular functions critical for maintaining homeostasis.
Pathways
AEBP1 integrates into the PPARγ signaling pathway. This pathway is important for adipocyte differentiation and lipid homeostasis. AEBP1's interaction with PPARγ connects it to the regulation of adipogenesis and metabolism. AEBP1 also participates indirectly in pathways modulating inflammatory responses. Through these connections AEBP1 influences proteins like C/EBPα which are key regulators of adipocyte commitment and growth.
AEBP1 has associations with obesity and inflammatory disorders. Its role in adipogenesis and inflammation links AEBP1 to obesity-related conditions where altered expression may contribute to weight gain and metabolic imbalances. Inflammatory disorders also involve AEBP1 as its modulation of immune-related factors can exacerbate or mitigate inflammation. Researchers recognize connections between AEBP1 and other proteins involved in these diseases such as NF-κB where AEBP1's regulation of inflammatory pathways could impact the progression of inflammatory diseases.
