Description
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q29432,
Animal free:No,
Carrier free:No,
Species:Cow,
Storage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pregnancy-associated glycoprotein 1 (PAG1) is a protein mainly associated with pregnancy in mammals. It belongs to the aspartic proteinase family and is encoded by the PAG1 gene. The protein has a molecular mass of approximately 50 kDa. PAG1 is expressed predominantly in the placenta and can also be found in serum. Its expression begins soon after conception and continues throughout pregnancy making it a useful marker for detecting early pregnancy in certain livestock species.
Biological function summary
PAG1 functions as a member of the aspartic proteinase family though its specific enzymatic activity in vivo remains not completely understood. It is involved in the formation and maintenance of the placenta possibly playing a role in trophoblastic cell invasion and immune modulation during pregnancy. PAG1 does not typically form large protein complexes but its presence in the placenta suggests a tight interaction with the developing fetal environment.
Pathways
PAG1 interacts with several molecular signaling pathways that involve placental development and fetal-maternal immune tolerance. One significant pathway is its role in the regulation of maternal immune response where PAG1 may contribute to the modulation of cytokine release. It is also involved with proteins like interferon tau which are important for successful pregnancy recognition and maintenance.
PAG1 is often linked to reproductive health challenges such as abnormal placental development and pre-eclampsia. Abnormal expression patterns of PAG1 can indicate placental dysfunction and irregularities during pregnancy. The protein may interact with factors like vascular endothelial growth factor (VEGF) which plays a role in angiogenesis and vascular function during pregnancy leading to its association with conditions involving placental insufficiency.
