Key facts
Reacts with:Human
Product details:
Lymphocyte Activation Gene 3 Antibody Panel ab252193 contains multiple trial-sized versions of anti-human antibody clones against Lymphocyte Activation Gene 3, specifically selected for high performance in IHC. This panel contains 6 recombinant rabbit monoclonal antibodies against human Lymphocyte Activation Gene 3. They are provided in trial sizes to allow you to easily evaluate which is the best Lymphocyte Activation Gene 3 antibody for your IHC research assay needs.
For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.
Panel contains:
- Rabbit monoclonal [CAL25] to Lymphocyte Activation Gene 3 (20 μL)
ab237718
- Rabbit monoclonal [CAL26] to Lymphocyte Activation Gene 3 (20 μL)
ab237719
- Rabbit monoclonal [CAL77] to Lymphocyte Activation Gene 3 (20 μL)
ab237720
- Rabbit monoclonal [EPR20261] to Lymphocyte Activation Gene 3 (20 μL)
ab209236
- Rabbit monoclonal [EPR4392(2)] to Lymphocyte Activation Gene 3 - C-terminal (20 μL)
ab180187
- Rabbit monoclonal [SP346] to Lymphocyte Activation Gene 3 - C-terminal (20 μL)
ab227706
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email
[email protected].
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LAG-3 also known as CD223 is a transmembrane protein with a mass of approximately 70 kDa. It acts as a checkpoint molecule similar to CTLA-4 and PD-1 in the immune system. LAG-3 is expressed on activated T cells natural killer cells and some dendritic cells. It interacts with its ligand MHC class II leading to inhibition of cellular proliferation and cytokine secretion an important part of immune response regulation.
Biological function summary
LAG-3 is involved in maintaining immune homeostasis and preventing autoimmunity. It is not part of a complex but works in synergy with other immune checkpoint molecules. When interacting with MHC class II LAG-3 transmits inhibitory signals that attenuate immune cell responses. Its role in immune regulation helps to balance immune activation and tolerance which is essential for preventing tissue damage while protecting against pathogens.
Pathways
The inhibitory role of LAG-3 integrates into the T cell receptor (TCR) signaling pathway and is also linked to the PD-1 signaling pathway. In TCR signaling LAG-3 negatively regulates T cell activation. LAG-3 is functionally related to proteins like PD-1 and CTLA-4 sharing similar roles in immune checkpoint pathways that are critical for maintaining immune balance.
LAG-3 has links to cancer and autoimmune diseases. In cancer LAG-3 expression on tumor-infiltrating lymphocytes correlates with immune evasion by tumors. This relationship appears in various cancers including melanoma and renal cell carcinoma. In autoimmune diseases LAG-3's expression on regulatory T cells helps control conditions such as multiple sclerosis. It collaborates with CTLA-4 in modulating immune responses that prevent excessive immune activation and tissue damage associated with autoimmunity.
