Key facts
Reacts with:Human,
Target:ITGAESee target data
Product details:
Dendritic Cell Marker (CD103, LY75/DEC-205, TLR7, DC-SIGN + DC-SIGNR) Antibody Panel - Human ab254017 contains multiple trial-sized versions of anti-human antibody clones against CD103, LY75 / DEC-205, TLR7, DC-SIGN + DC-SIGNR, specifically selected for high performance in various applications. This panel contains 4 recombinant rabbit monoclonal antibodies against human CD103, LY75/DEC-205, TLR7, DC-SIGN + DC-SIGNR. They are provided as a sampler panel to allow you to easily evaluate each in your required applications.
For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.
Panel contains:
- Rabbit monoclonal [EPR4166(2)] to CD103 (20 μL)
ab129202
- Rabbit monoclonal [EPR5233] to LY75/DEC-205 (20 μL)
ab124897
- Rabbit monoclonal [EPR2088(2)] to TLR7 (20 μL)
ab124928
- Rabbit monoclonal [EPR22395-72] to DC-SIGN + DC-SIGNR (20 μL)
ab245115
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email
[email protected].
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LY75 also known as DEC-205 is a receptor that plays a role in antigen capture and presentation. It has a mass of about 205 kDa. Expressed on the surface of dendritic cells (DC) DEC-205 is considered an important marker for these immune cells. CD103 DC also use the DEC-205 pathway for their functions. Additionally DC-SIGN and its related receptor DC-SIGNR are other DC markers aiding in pathogen recognition. TLR7 part of the Toll-like receptor family is involved in the detection of single-stranded RNA contributing to immune responses.
Biological function summary
LY75/DEC-205 and associated DC markers function in the identification and processing of antigens. They recognize specific ligands and internalize them for processing and presentation to T cells. DEC-205 plays an important role in cross-presentation important for activating cytotoxic T cells. This receptor is part of a larger complex involving other C-type lectin receptors like DC-SIGN that are also present in dendritic cells. These receptors work together to enhance immune responses against pathogens.
Pathways
LY75/DEC-205 and related DC markers are integral to the antigen presentation pathways that activate T lymphocytes. These pathways include the major histocompatibility complex (MHC) class I and II pathways. DEC-205's role in the cross-presentation pathway allows DCs to present antigens to CD8+ T cells often in collaboration with CD103-mediated processes. Related proteins like CD40 and CD80/CD86 are also engaged during T cell priming enhancing immune activation.
LY75/DEC-205 has implications in autoimmunity and infectious diseases. Autoimmune conditions can arise when improper antigen presentation leads to self-reactive T cells. For example faulty presentation in DEC-205 pathways may link to diseases like rheumatoid arthritis. In infectious diseases receptors like DC-SIGN interact with pathogens such as HIV mediating viral entry and immune evasion. Proteins like TLR7 also connect to immune-related disorders by regulating responses to viral infections.
