Key facts
Reacts with:Mouse, Human,
Target:ATP1A1See target data
Product details:
Plasma Membrane Marker (Na/K ATPase, pan Cadherin, PMCA1) Antibody Sampler Panel - Human, Mouse ab254025 contains multiple trial-sized versions of anti-human and mouse antibody clones against Na/K ATPase, pan Cadherin, PMCA1, specifically selected for high performance in various applications. This panel contains 3 recombinant rabbit monoclonal antibodies against Na K ATPase, pan Cadherin, PMCA1 and 2 mouse monclonals against Na K ATPase, Cadherin. They are provided as a sampler panel to allow you to easily evaluate each in your required applications.
For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.
Panel contains:
- Rabbit monoclonal [EP1845Y] to Sodium Potassium ATPase - Plasma Membrane Loading Control (20 μL)
ab76020
- Mouse monoclonal [464.6] to alpha 1 Sodium Potassium ATPase (20 μg)
ab7671
- Rabbit monoclonal [EPR1792Y] to pan Cadherin - Intercellular Junction Marker (20 μL)
ab51034
- Mouse monoclonal [mAbcam22744] to pan Cadherin (20 μg)
ab22744
- Rabbit monoclonal [EPR12029] to PMCA1 (20 μL)
ab190355
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email
[email protected].
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pan Cadherin Sodium Potassium ATPase PMCA1 and Alpha 1 Sodium Potassium ATPase are essential membrane proteins with primary roles in cellular functions. Pan Cadherins are proteins involved in cell-cell adhesion helping maintain the structure of tissue. Sodium Potassium ATPase often called the Na+/K+ pump is a vital transporter involved in maintaining the electrochemical gradients of sodium and potassium ions across the plasma membrane. This ATPase is made up of alpha and beta subunits with the alpha 1 subunit having a mass of approximately 100 kDa. PMCA1 or Plasma Membrane Calcium ATPase 1 actively removes calcium from the cell interior contributing to calcium homeostasis. These proteins find expression in various tissues and cell types particularly on the plasma membrane serving as critical plasma membrane markers.
Biological function summary
These proteins contribute to essential cellular processes such as signaling volume regulation and ion homeostasis. Pan Cadherins interact with actin filaments forming complexes with catenins to facilitate adhesion and signaling. Sodium Potassium ATPase serves multiple functions such as controlling cell volume and generating resting membrane potential important for nerve impulse transmission. It forms a complex with other proteins such as ankyrin and spectrin contributing to its transport function. PMCA1 regulates intracellular calcium levels forming complexes with calmodulin regulating numerous cellular processes including muscle contraction and neurotransmitter release.
Pathways
Sodium Potassium ATPase plays a significant role in pathways that involve ion transport and membrane potential regulation. It is integral to the WNT signaling pathway influencing cellular events such as proliferation and differentiation. Related proteins like NCX (Sodium Calcium Exchanger) also participate in these pathways ensuring the balance of ions and cellular homeostasis. PMCA1 is known to be involved in calcium signaling pathways critical for managing cellular responses and interactions with proteins like calmodulin and SERCA (Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase).
These proteins significantly impact cardiovascular diseases and neurological conditions. Sodium Potassium ATPase malfunctions link to hypertension and cardiac fibrosis due to its role in blood pressure regulation and heart function. In these conditions proteins like angiotensin-converting enzyme (ACE) associate with Sodium Potassium ATPase activity. Dysfunction in PMCA1 can lead to neurodegenerative diseases given its role in maintaining calcium homeostasis within neurons. Proteins such as alpha-synuclein and tau which correlate with neurological conditions are impacted by altered calcium levels managed by PMCA1.
