Description
Key facts
CAS number:364782-34-3,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:393.9 Da,
Molecular formula:C22H23ClF3N,
PubChem:156418,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100mM,
Biochemical name:Cinacalcet hydrochloride,
Biological description:Ca2+-sensing receptor agonist that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. Decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, lowers oxidative stress and displays anti fibrotic activity. Increases sensitivity of Ca2+-sensing receptors to serum Ca2+ levels. In vivo. Decreases renal epithelial-to-mesenchymal transition (EMT) and prevents the development of renal fibrosis.,
Canonical smiles:CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl,
Isomeric smiles:C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl,
InChi:InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1,
InChiKey:QANQWUQOEJZMLL-PKLMIRHRSA-N,
IUPAC Name:N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine;hydrochloride
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-Ambient
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Estrogen Receptor beta (ERβ) and ROR gamma also known as NR3C2 and RORG are part of the nuclear receptor family of intracellular transcription factors. ERβ has a molecular mass of approximately 59 kDa while ROR gamma's mass is about 55 kDa. ERβ primarily binds estrogen and regulates gene expression playing a role in reproductive tissues cardiovascular system and brain. ROR gamma functions as a regulatory transcription factor in numerous immune cells and affects the expression of genes related to inflammation and metabolism.
Biological function summary
These receptors mediate diverse physiological processes. Estrogen Receptor beta acts in tissues by influencing cellular proliferation and differentiation processes often forming complexes with other transcriptional regulators. ROR gamma significantly participates in thymocyte differentiation and the production of pro-inflammatory cytokines contributing to immune response modulation. These functions are critical in maintaining homeostasis and adaptive responses.
Pathways
ERβ and ROR gamma engage in distinct but intersecting signaling cascades. ERβ is involved in the estrogen signaling pathway and interacts with proteins such as coactivators and corepressors influencing processes like cell cycle regulation. ROR gamma influences the Th17 cell differentiation pathway where it cooperates with transcription factors like STAT3 to regulate immune cell differentiation. Together these pathways highlight the varied roles they play in both cellular metabolism and immunity.
Disturbances in ERβ and ROR gamma activity have implications in health. Alterations in ERβ function correlate with breast cancer development and progression where it interacts with proteins like p53. ROR gamma has been linked to autoimmune conditions such as psoriasis interacting with key inflammatory molecules including IL-17A. Research on these receptors continues to uncover their roles in pathophysiology offering insights for therapeutic interventions.
