Key facts
Reacts with:Human,
Target:BDNFSee target data
Product details:
Neuroinflammation Marker (BDNF, ICAM1, TREM2, GFAP, TNF alpha, Iba1) Antibody Panel - Human ab263462 contains multiple trial-sized versions of anti-human antibody clones against BDNF, ICAM1, TREM2, GFAP, TNF alpha, Iba1, specifically selected for high performance in various applications. They are provided as a sampler panel to allow you to easily evaluate each antibody.
For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.
Panel contains:
- Rabbit monoclonal [EPR1292] to BDNF (20 μL)
ab108319
- Rabbit monoclonal [EP1442Y] to ICAM1 (20 μL)
ab53013
- Rabbit monoclonal [EPR20243] to TREM2 (20 μL)
ab209814
- Rabbit monoclonal [EP672Y] to GFAP (20 μL)
ab33922
- Rabbit monoclonal [EPR20972] to TNF alpha (20 μL)
ab215188
- Rabbit monoclonal [EPR16589] to Iba1 (20 μL)
ab178847
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email
[email protected].
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ICAM1 (Intercellular Adhesion Molecule 1) TNF alpha (Tumor Necrosis Factor-alpha) GFAP (Glial Fibrillary Acidic Protein) BDNF (Brain-Derived Neurotrophic Factor) Iba1 (Ionized Calcium Binding Adapter Molecule 1) and TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) serve important roles in cell signaling and tissue integrity. ICAM1 is a 55–65 kDa transmembrane protein expressed on endothelial cells and immune cells mediating leukocyte adhesion and transmigration. TNF alpha a cytokine expressed by macrophages has a mass of 17 kDa in its secreted form and acts in inflammatory responses. GFAP found in astrocytes helps maintain the cytoskeletal structure and its mass is about 50 kDa. BDNF is a neurotrophin important for neuronal survival and growth. Iba1 with a mass of approximately 17 kDa is expressed in microglia. TREM2 is present on macrophages and microglia as a receptor involved in phagocytosis and inflammation control.
Biological function summary
These proteins engage in essential processes such as immune response and neuroprotection. ICAM1 facilitates immune cell interactions and recruitment during inflammation. TNF alpha an important inflammatory molecule promotes apoptosis and inflammation. GFAP structurally supports glial cells and guides neuronal development. BDNF encourages neuronal differentiation and synaptic plasticity. Iba1 serves as a neuroinflammatory marker connecting microglial responses to central nervous system health. TREM2 forming part of receptor complexes supports phagocytosis and manages immune signaling impacting clearances like debris or apoptotic cells.
Pathways
These proteins integrate into significant biological networks such as the NF-kB and MAPK pathways impacting immunity and homeostasis. ICAM1 interacts within pathways that regulate leukocyte extravasation. TNF alpha serves as a cytokine in the TNF receptor pathway influencing apoptosis and survival. BDNF activates TrkB receptors promoting MAPK and PI3K/Akt pathways for neuronal survival. Iba1 and TREM2 work in the microglial response pathway coordinating with CD45 markers to modulate neuroinflammatory markers and immunofluorescence dynamics. GFAP fits into astrocyte signaling pathways contributing to brain architecture and repair.
These proteins relate to various conditions like Alzheimer’s disease and multiple sclerosis. ICAM1 and TNF alpha correlate with inflammatory disorders disrupting normal immune responses. TNF alpha contributes to chronic inflammation and autoimmunity in diseases. BDNF levels influence neurodegenerative diseases with low levels implicated in brain dysfunctions. Iba1 and TREM2 are important in Alzheimer's as changes in their expression affect microglial activity and amyloid-beta clearance with TREM2 mutations enhancing risk. GFAP serves as a marker for astrocyte reactivity in multiple sclerosis and brain injuries while closely linking to Iba1 for assessing glial response to central nervous system damage.
