Key facts
Reacts with:Mouse, Rat, Human,
Target:SNCASee target data
Product details:
Alpha Synuclein Antibody Sampler Panel ab263465 contains multiple trial-sized versions of anti-human, mouse, and rat antibody clones against Alpha Synuclein, specifically selected for high performance in various applications. This panel contains 4 recombinant rabbit monoclonal antibodies and 2 mouse monoclonal antibodies against Alpha Synuclein. They are provided as a sampler panel to allow you to easily evaluate each antibody.
For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.
Panel contains:
- Rabbit monoclonal [EP1536Y] to Alpha-synuclein (phospho S129) (20 μL)
ab51253
- Rabbit monoclonal [MJFR1] to Alpha-synuclein (20 μL)
ab138501
- Rabbit monoclonal [MJFR-14-6-4-2] to Alpha-synuclein filament - Conformation-Specific (20 μL)
ab209538
- Mouse monoclonal [LB 509] to Alpha-synuclein (20 μg)
ab27766
- Mouse monoclonal [syn211] to Alpha-synuclein (20 μg)
ab80627
- Rabbit monoclonal [EPR20535] to Alpha-synuclein (20 μL)
ab212184
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email
[email protected].
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha-synuclein often referred to as SNCA or NACP is a protein that plays important mechanical roles in the nervous system. It possesses a mass of approximately 14 kDa and is known for its expression predominately in the brain especially within the presynaptic terminals of neurons. Its primary function involves binding to phospholipids and regulating synaptic vesicle trafficking affecting the release of neurotransmitters. Alpha-synuclein can also adopt multiple conformations including monomeric and aggregated forms which can affect its functional capabilities.
Biological function summary
Alpha-synuclein impacts several cellular processes including neuronal function and plasticity. It can form aggregates known as Lewy bodies which are distinctive in certain neurodegenerative diseases. Alpha-synuclein is associated with the regulation of dopamine release and uptake affecting synaptic activity and neural communication. Within cells it does not necessarily function as part of a larger protein complex but interacts dynamically with cellular membranes and other synaptic proteins impacting cellular homeostasis and stress response.
Pathways
This protein integrates into key neuronal processes such as the synaptic vesicle cycle and the autophagy-lysosome pathway. It affects interactions with other proteins like PARK7 (DJ-1) and LRRK2 which influence neurodegenerative processes. Alpha-synuclein’s behavior in protein folding and degradation pathways hints at its role in maintaining protein homeostasis under normal and pathological conditions. Its involvement in the autophagy pathway connects its function to cellular clearing mechanisms and responses to cellular stress.
Alpha-synuclein is linked prominently to Parkinson's disease and dementia with Lewy bodies. These conditions feature the pathological aggregation of alpha-synuclein into insoluble fibrils. Aberrant interactions with proteins such as tau and ubiquitin may exacerbate pathological conditions and contribute to disease progression. These aggregates disrupt cellular functions leading to neuron loss and impaired neural networks highlighting alpha-synuclein as a significant focus in neurodegenerative disease research.
