Description
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp insertion in exon 1,
Disease:Adenocarcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-FZD2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Frizzled 2 (FZD2) is a member of the Frizzled receptor family which plays a role in the Wnt signaling pathway. FZD2 also known by alternate names like FzE2 and HFzd2r is a membrane-bound receptor with a mass of approximately 70 kDa. This protein is expressed in various tissues including the brain heart and lungs indicating its involvement in multiple cellular processes. The receptor contains a distinct structure comprising seven transmembrane domains which facilitates its interaction with other molecules and downstream signaling components.
Biological function summary
FZD2 acts as a critical mediator within the Wnt signaling pathway and it often functions as part of the Frizzled receptor complex. This protein binds to secreted Wnt ligands initiating intracellular signaling cascades that regulate cell fate proliferation and differentiation. Through these interactions FZD2 influences embryonic development and tissue homeostasis. The receptor's role in these fundamental processes highlights its importance in maintaining proper cellular and organismal function.
Pathways
FZD2 participates in the canonical Wnt/β-catenin and non-canonical Wnt signaling pathways. In the canonical pathway FZD2 assists in the stabilization and accumulation of β-catenin in the cytoplasm which ultimately translocates to the nucleus to regulate gene expression. In the non-canonical pathway FZD2 plays a part in the planar cell polarity and Wnt/Ca2+ pathways. Proteins like Dishevelled (DVL) and LRP5/6 are closely related to FZD2 facilitating its role in diverse signaling events important for development and cellular dynamics.
FZD2's involvement in the Wnt signaling pathway associates it with conditions like cancer and osteoporosis. Aberrant FZD2 signaling can contribute to tumorigenesis since alterations in Wnt pathways often lead to uncontrolled cell division and cancer progression. Similarly defects in Wnt-mediated bone formation can link FZD2 to osteoporosis. In these contexts FZD2 interacts with proteins such as β-catenin and Dkk1 which help mediate its effects on disease pathogenesis and progression.
