Description
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp deletion in exon 1,
Disease:Adenocarcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-ETNK1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ethanolamine kinase often referred to as ETNK1 is an enzyme known for its role in phospholipid metabolism. It catalyzes the phosphorylation of ethanolamine to produce phosphoethanolamine. This enzyme has a molecular weight of approximately 45 kDa. Ethanolamine kinase is expressed in various tissues including liver and brain indicating its importance in systemic metabolic processes.
Biological function summary
The enzyme is involved in the Kennedy pathway which is responsible for the biosynthesis of phosphatidylethanolamine an important membrane lipid. Ethanolamine kinase operates independently and is not part of any larger protein complex. It supports cellular functions including membrane formation and repair which are critical for proper cell function and signaling.
Pathways
Ethanolamine kinase plays a significant role in the phospholipid biosynthesis pathway and the related glycerophospholipid metabolism pathway. In these pathways it interacts with other enzymes like CTP:phosphoethanolamine cytidylyltransferase shaping the production and regulation of membrane phospholipids. These pathways are essential for maintaining cellular membrane integrity and fluidity.
Ethanolamine kinase has been linked to neurological disorders. Abnormalities in its function can lead to issues in brain phospholipid metabolism potentially contributing to conditions like Alzheimer's disease. Additionally alterations in ethanolamine kinase expression or activity might impact proteins involved in neurodegenerative processes further influencing disease progression.
