Description
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,Western blot,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 1 and 2 bp deletion in exon 1,
Disease:Adenocarcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-CUTC, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Western blot, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CUTC also known as copper homeostasis protein CUTC plays a role in copper transport and homeostasis. It has a molecular mass of approximately 30 kDa. CUTC expression occurs mainly in the liver kidney and intestines suggesting its importance in managing systemic copper levels. CUTC contains several copper-binding motifs that help it in coordinating and potentially transporting copper ions across cellular compartments.
Biological function summary
Copper homeostasis protein CUTC functions in the regulation of intracellular copper levels and may interact with copper chaperones. The protein does not work in isolation but instead might form complexes with other copper-binding proteins to facilitate efficient copper regulation. Proper function of CUTC is necessary for various copper-dependent enzymatic activities highlighting its role in maintaining cellular copper sufficiency.
Pathways
CUTC is engaged in the copper homeostasis pathway that ensures adequate copper distribution and detoxification. This protein is associated with other copper-related proteins like ATP7A/B which transport copper across cellular membranes. Through these interactions CUTC assists in protecting cells from copper toxicity and supports essential biological functions requiring copper.
CUTC relates to Wilson's disease and Menkes disease which are disorders of copper metabolism. CUTC interacts with proteins such as ATP7B in Wilson's disease and ATP7A in Menkes disease. Understanding CUTC's function and interactions is key for developing therapeutic strategies aimed at alleviating symptoms associated with impaired copper homeostasis in these conditions.
