Description
Key facts
Cell type:HeLa,
Species or organism:Human,
Tissue:Cervix,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 1 bp deletion in exon 1,
Disease:Adenocarcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-ADCK2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADCK2 also known as AarF Domain Containing Kinase 2 is a protein kinase with an approximate mass of 74 kDa. It displays expression mostly in mitochondrial compartments where it exhibits its mechanical role of transferring phosphates to substrate proteins. This kinase belongs to the ABC1 (Activity of bc1 complex) family of atypical kinases which are characterized by specific serine/threonine phosphorylation activities in various organisms.
Biological function summary
ADCK2 is involved in cellular energy production processes. It maintains a role in the mitochondrial function influencing synthesis and maintenance of the respiratory chain complexes. Although ADCK2 is not a part of the protein complexes directly it acts as a modifier that affects the efficiency of these complexes in energy metabolism. Researchers often focus on its impact within the mitochondrial dynamics realm which is important for cellular health and activity.
Pathways
ADCK2 holds a role in both coenzyme Q biosynthesis and oxidative phosphorylation pathways. Coenzyme Q biosynthesis pathway connects ADCK2 function with several Q biosynthesis proteins such as COQ6. In oxidative phosphorylation ADCK2 contributes indirectly by affecting the electron transport chain's efficiency where it indirectly interacts with proteins such as cytochrome c oxidase components playing roles in ATP production.
Altered ADCK2 expression has relations with mitochondrial myopathies and certain metabolic syndromes. These conditions often involve dysfunctions within the energy production process linking ADCK2 with proteins like COQ10 which are important in the respiratory chain. As such ADCK2 represents a potential target in understanding and addressing these metabolic imbalances and related clinical presentations.
