Description
Key facts
Cell type:A549,
Species or organism:Human,
Tissue:Lung,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon 9 and 1 bp insertion in exon 9,
Disease:Carcinoma
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-HELZ2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HELZ2 also known as Helicase Like Transcription Factor 2 is a protein characterized by its capacity to bind DNA and RNA. It possesses a DEAD box domain which makes it part of the DExH/D box helicases. HELZ2 has a molecular mass of about 247 kDa. This protein is widely expressed in various tissues especially abundant in the liver and brain. Additional research highlights its presence in the adipose tissue indicating its potential role in metabolic processes.
Biological function summary
HELZ2 functions in gene expression regulation by interacting with nuclear receptors and transcription factors. It acts within a protein complex influencing transcriptional regulation through chromatin remodeling. By modulating key transcriptional activities HELZ2 affects numerous genetic pathways and signal transductions contributing to fundamental cellular functions including development and differentiation. Knockout studies of HELZ2 dbd or domain-binding disruption suggest significant involvement in cellular homeostasis.
Pathways
This protein plays significant roles in lipid metabolism and the insulin signaling pathway. HELZ2 has connections to related proteins such as PPAR and SREBPs involved in regulating lipid homeostasis and metabolic balance. Through these pathways HELZ2 navigates the intricate regulatory network that maintains metabolic equilibrium exhibiting a profound influence on cellular metabolic processes.
HELZ2 is linked to obesity and type 2 diabetes due to its role in metabolic regulation. By interacting with PPAR and other metabolic regulators HELZ2 has implications in adipogenesis and energy homeostasis which are critical in the pathogenesis of these metabolic disorders. Understanding its function may offer insights into potential therapeutic targets for these conditions.
