Description
Key facts
Cell type:HEK-293T,
Species or organism:Human,
Tissue:Kidney,
Form:LiquidSee storage information,
Knockout validation:Sanger Sequencing,
Mutation description:Knockout achieved by using CRISPR/Cas9, Homozygous: 4 bp deletion in exon 2
Product details:
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages
Properties and Storage Information:
Gene name-APBB1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FE65 also known as APBB1 is a protein with a molecular mass of approximately 65 kDa. It belongs to the family of adaptor proteins with important roles in different cellular processes. This protein is expressed abundantly in the brain particularly in neurons where it interacts with other proteins to mediate signaling pathways. FE65 contains several conserved domains including a WW domain and two phosphotyrosine-binding (PTB) domains which facilitate its interaction with multiple partners.
Biological function summary
FE65 plays a significant role in neuronal development and cognitive functions. It is part of a protein complex that includes the amyloid precursor protein (APP). This complex is important for the regulation of gene expression and cellular communication. FE65 also affects the nuclear signaling by interacting with the chromatin-remodeling complex. These interactions suggest that FE65 has a hand in influencing transcriptional activities within the cell.
Pathways
FE65 is involved in the APP processing pathway and the development of Alzheimer's disease. It interacts with APP and influences its role in the cleavage and formation of amyloid-beta peptides. These peptides are key factors within the Alzheimer's disease pathway. Moreover FE65 connects with other proteins such as Abl which is involved in cell differentiation and migration processes. Through these pathways FE65 contributes to a broad range of neuronal functions and activities.
FE65 has a close connection to Alzheimer's disease and cognitive impairments. In Alzheimer's disease FE65 interacts with APP modulating the production of amyloid-beta an important pathological component of the disease. The accumulation of amyloid-beta is linked to the progression of symptoms in Alzheimer's patients. Additionally FE65 is associated with other proteins related to neuronal dysfunction and synaptic plasticity which may impact cognitive disorders.
