Description
Key facts
Purity:>70% SDS-PAGE,
Expression system:Baculovirus infected Sf9 cells,
Tags:Tag free,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:The specific activity of ab268852 was 8 nmol/min/mg in a kinase assay using Phosphatidylinositol 4,5-bisphosphate [PI(4,5P2)] as substrate.,
Accession:P42336,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Product details:
Subunits co-expressed.
Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PI 3 Kinase p55 gamma also known as PIK3CA or phosphoinositide 3-kinase catalytic subunit alpha is an enzyme that adds phosphate groups to the 3-position of the inositol ring of phosphatidylinositol lipids. It is approximately 124 kDa in size and is expressed in various tissues including the liver muscle and brain. Its main role is to regulate different cellular processes such as cell growth proliferation differentiation motility and survival.
Biological function summary
PI 3 Kinase p55 gamma acts as an important player in the signal transduction pathways by participating in the PI3K/AKT signaling pathway. It is part of a heterodimeric complex that includes a regulatory subunit typically p85. This interaction allows the protein to transmit signals from outside the cell to the nucleus influencing cellular functions related to metabolism and growth.
Pathways
PI 3 Kinase p55 gamma is important in the PI3K/AKT and mTOR pathways. These pathways are important for cell cycle progression and survival influencing how cells respond to external signals. This protein also interacts with other important proteins such as AKT and mTOR which are instrumental in translating extracellular signals into responses that promote cellular growth and proliferation.
PI 3 Kinase p55 gamma is closely linked with cancer and metabolic diseases. Mutations and overexpression of PIK3CA are found in several cancers including breast and colon cancer where it influences tumor growth and survival by altering cellular signaling. Additionally it is associated with metabolic disorders like insulin resistance connecting with proteins such as the insulin receptor substrate. These associations make PIK3CA a significant target in therapeutic interventions.
