Key facts
Reacts with:Human,
Target:CD274See target data
Product details:
Immune Checkpoint Inhibitors Panel - Human WB ab278172 contains multiple trial-sized versions of anti-human antibody clones against PD-L1, PD-L2, PD1, LAG3, TIM 3, VISTA, CTLA4 and TIGIT specifically selected for high performance in various applications. They are provided as a sampler panel to allow you to easily evaluate each antibody.
For guidelines on how to use each antibody within the panel, please consult the individual datasheet for each antibody.
Panel contains:
- Rabbit monoclonal [73-10] to PD-L1 (20 μL)
ab228415
- Rabbit monoclonal [CAL28] to PD-L2 (20 μL)
ab256386
- Rabbit monoclonal [EPR23119-111] to PD1 (20 μL)
ab243644
- Rabbit monoclonal [EPR20261] to LAG-3 (20 μL)
ab209236
- Rabbit monoclonal [EPR22241] to TIM 3 (20 μL)
ab241332
- Rabbit monoclonal [EPR21050] to VISTA (20 μL)
ab230950
- Rabbit monoclonal [CAL49] to CTLA4 (20 μL)
ab237712
- Rabbit monoclonal [BLR047F] to TIGIT - BSA free (20 μL)
ab243903
Explore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.
Carrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email
[email protected].
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTLA4 TIM-3 PD-L2 PD1 LAG-3 PD-L1 VISTA and TIGIT are co-inhibitory receptors involved in immune regulation. These proteins regulate T cell responses and tolerance by delivering inhibitory signals that down-modulate effector functions. For example CTLA4 sometimes called CD152 is a 33 kDa protein expressed on regulatory T cells and activated conventional T cells. PD-1 known as PDCD1 is a 55 kDa protein expressed on activated T cells B cells and myeloid cells. These proteins localize mainly at the immune synapse and influence immune signaling pathways.
Biological function summary
These proteins play critical roles in the immune system. They form complexes that send signals to T cells to reduce their activity preventing overactivation that can lead to autoimmune conditions. TIM-3 is particularly involved in inhibiting T cell responses and is expressed on Th1 and cytotoxic T cells. PD-L1 the ligand for PD-1 can be found on antigen-presenting cells and some tumor cells also contributing to immune evasion by tumors.
Pathways
These receptors participate in multiple signaling pathways key to maintaining immune homeostasis. The PD-1/PD-L1 pathway modulates T cell activity during antigen presentation significantly impacting pathways related to immune tolerance. CTLA4 interacts with the CD28 receptor pathway providing a checkpoint in immune activation. These interactions often involve proteins such as B7-1 and B7-2 which are costimulatory molecules that further regulate immune responses.
These proteins have associations with autoimmune diseases and cancer. Dysregulation of CTLA4 for instance links to autoimmune disorders like rheumatoid arthritis. PD1 and PD-L1 have roles in cancer because tumors often exploit these pathways to avoid immune detection. Inhibition of these checkpoint proteins with therapeutic antibodies has shown promise in cancer treatment. Studies also highlight interactions with proteins such as CD28 and PD1 essential factors in understanding their roles in immune evasion and disease progression.
