Description
Key facts
CAS number:1143532-39-1,
Purity:>95%,
Form:SolidSee storage information,
Molecular weight:428.9 Da,
Molecular formula:C21H25ClN6O2,
PubChem:25227436,
Nature:Synthetic,
Solubility:Soluble in DMSO (up to 21.45 mg/mL),
Biochemical name:Capivasertib,
Biological description:A novel pyrrolopyrimidine derivative. A potent inhibitor of all AKT isoforms, IC50 <10 nM, with potential antineoplastic activity.,
Canonical smiles:C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4,
Isomeric smiles:C1CN(CCC1(C(=O)N[C@@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4,
InChi:InChI=1S/C21H25ClN6O2/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26)/t17-/m0/s1,
InChiKey:JDUBGYFRJFOXQC-KRWDZBQOSA-N,
IUPAC Name:4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Product details:
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AKT also known as protein kinase B (PKB) is a serine/threonine kinase with a molecular weight of approximately 56 kDa. It plays an important role in signaling pathways regulating cellular processes such as glucose uptake cell survival and growth. AKT is expressed in various tissues including muscle and liver and is often observed using techniques like Western blot. Its kinase activity involves phosphorylation which is essential for its full activation and subsequent biological functions.
Biological function summary
AKT influences cell proliferation and apoptosis. As part of a signaling complex AKT phosphorylation modulates several downstream targets important for cell cycle progression and survival. Its activation depends on upstream kinases like PI3K and PDK1 positioning AKT as a central node in cellular responses. By mediating these processes AKT directly impacts organismal growth and stress response mechanisms.
Pathways
AKT is central to the PI3K/AKT/mTOR and insulin signaling pathways both important for cellular metabolism and growth regulation. It interacts with proteins such as mTOR and GSK3 which are involved in cell growth and glycogen synthesis respectively. These interactions show AKT's pivotal role in maintaining cellular energy balance and metabolic processes.
AKT is frequently linked to cancer and type 2 diabetes. Its abnormal regulation contributes to oncogenesis through uncontrolled cell proliferation and survival. AKT is also associated with insulin resistance in diabetes where it affects glucose metabolism. Through these conditions proteins like PTEN and IRS1 interact with or regulate AKT highlighting its significance in disease states and its potential as a therapeutic target.
