Description
Key facts
CAS number:1589527-65-0,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:518.5 Da,
Molecular formula:C28H25F3N6O,
PubChem:73425700,
Nature:Synthetic,
Solubility:~20 mg/ml in DMSO,
Biochemical name:1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea,
Biological description:An ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 μM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.,
Canonical smiles:CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F,
InChi:InChI=1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38),
InChiKey:NOHQEAFAESMMDX-UHFFFAOYSA-N,
IUPAC Name:1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea
Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2594 KIRA6. B2594-5 is the same size as the 5 mg size of ab287101.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark
