Abcam, ab288432-200µg, Anti-TCR alpha antibody [Desire-1]

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TCR alpha plays a central role in immune response by recognizing antigens presented by MHC. TCR alpha chain is part of a larger T cell receptor complex which includes the CD3 signaling molecules. The binding of antigens triggers a signal transduction cascade through CD3 components leading to T cell activation proliferation and differentiation into effector T cells. These effector cells then participate in immune defenses against pathogens and are important for immune surveillance. TCR alpha's interaction with the environment and antigens initiates immune synapse formation leading to proper signal transmission.
Pathways
TCR alpha is an important participant in the T cell receptor signaling pathway. This pathway plays an important role in T cell activation and function linking innate and adaptive immunity. TCR alpha interacts with several signaling proteins such as Lck and ZAP-70 which propagate the signal downstream to various transcription factors that modulate gene expression. This cascade affects cellular processes including cytokine production and survival further connecting the TCR signaling pathway to other pathways like the MAP kinase signaling pathway.