Abcam, ab316876-100µL, Alexa Fluor® 488 Anti-EMR1/ADGRE1 (F4/80) antibody [EPR23225-94]

Product details
Patented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The function of EMR1 plays an important role in the immune system especially in myeloid cell function. It does not exist alone but rather forms a part of the complex cell adhesion molecules contributing to cell-cell interactions and migrations. By doing so it supports immune surveillance and inflammation processes. It impacts the differentiation and survival of macrophages hence directly influencing host defense.
Pathways
EMR1's involvement extends to several cellular signal transduction pathways. Notably it plays a part in the immune response pathway and the GPCR signaling pathway where it interacts with related proteins such as CD11b and other integrins. These pathways ensure proper communication and activation of immune cells which is important for a coordinated immune response. Its interaction with other adhesion molecules suggests an integrated role in initiating signaling cascades that affect immune cell positioning and activation.