Abcam, ab318245-100µL, Alexa Fluor® 488 Anti-GPCR LGR6 antibody [EPR6874]

Product details
Patented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].

Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LGR6 plays an important role in signaling pathways involved in stem cell maintenance and tissue regeneration. It functions together with other proteins as part of a larger receptor complex. In the skin LGR6 marks a population of stem cells involved in hair follicle cycling and epidermal renewal. Its activity influences the cellular communication required for tissue homeostasis and repair. This receptor helps in determining cellular fate and proliferation in various tissues.
Pathways
LGR6 participates in the Wnt signaling pathway which is important for cell differentiation growth and migration. LGR6 interacts with proteins such as R-spondins enhancing Wnt signaling. This connection highlights LGR6's role in modulating pathways essential for embryonic development and tissue patterning. The interaction with Wnt and related proteins positions LGR6 as a modulator of pathways that govern stem cell behavior.