Description
Key facts
Purity:>90% Densitometry,
Expression system:Native,
Tags:Tag free,
Applications:SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P81558,
Animal free:No,
Carrier free:No,
Species:Pig,
Storage buffer:pH: 6.5
Product details:
ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for the following active protein kinases:
ab51441
(Active human MNK2 full length protein)
ab55709
(Active human Flt3 / CD135 protein fragment)
ab55716
(Active human Myosin IIIB protein fragment)
ab56636
(Active human MAP4K5 full length protein)
ab60327
(Active mouse Aurora A full length protein)
ab60342
(Active human NEK2 full length protein)
ab60698
(Active human NEK6 full length protein)
ab60860
(Active human IRAK4 full length protein)
ab60867
(Active human HIPK1 protein fragment)
ab60879
(Active human RIP2 protein)
ab60885
(Active human STK3 full length protein)
ab61426
(Active human TAO kinase 2 protein fragment)
ab63169
(Active human TAOK1 protein fragment)
ab63191
(Active human DAP Kinase 1 protein fragment)
ab63192
(Active human ZIP Kinase full length protein)
ab63209
(Active human MEK1 full length protein)
ab64303
(Active human CDK7 + Cyclin H + MNAT1 full length protein)
ab69925
(Active human HIPK4 full length protein)
ab70075
(Active human TSSK2 full length protein)
ab70614
(Active human ROR2 protein fragment)
ab71693
(Active MUSK protein fragment)
ab85275
(Active human PBK full length protein)
ab85276
(Active human NAK full length protein)
ab85293
(Active human SRPK2 full length protein)
ab85295
(Active human SRPK1 full length protein)
ab85297
(Active human MEKK3 full length protein)
ab85299
(Active human MEKK2 full length protein)
ab85601
(Active human HIPK3 protein fragment)
ab85759
(Active human CLK3 full length protein)
ab85838
(Active human PKR protein fragment)
ab89589
(Active human Mps1 full length protein)
ab89591
(Active human STK33 full length protein)
ab89692
(Active human TAK1 + TAB1 protein fragment)
ab89694
(Active human RIPK5 full length protein)
ab89758
(Active human NEK3 full length protein)
ab89852
(Active human ZAK full length protein)
ab101774
(Active human ICK full length protein)
ab101775
(Active human MAP4K4 protein fragment)
ab104027
(Active human MEKK1 protein fragment)
ab105210
(Active human NFkB Inducing Kinase NIK protein fragment)
ab105904
(Active human ERK1 full length protein)
ab107696
(Active human STK39 full length protein)
ab107700
(Active human NLK full length protein)
ab107953
(Active human MAP4K1 protein)
ab119725
(Active human TNIK protein fragment)
ab125544
(Active human NEK11 full length protein)
ab125553
(Active mouse HIPK2 protein fragment)
ab125554
(Active human MAP3K9 protein fragment)
ab125558
(Active human PLK4 protein fragment)
ab125562
(Active human MLK2 protein fragment)
ab125566
(Active human RIP3 full length protein)
ab125574
(Active human YANK2 full length protein)
ab125588
(Active human STK25 full length protein)
ab125614
(Active human NEK9 protein fragment)
ab125622
(Active human ULK2 protein fragment)
ab125630
(Active human MLK3 protein fragment)
ab125631
(Active mouse Tau tubulin kinase 2 protein fragment)
ab125656
(Active human ULK1 protein fragment)
ab126913
(Active human ERK5 full length protein)
ab126926
(Active human BMPR2 protein fragment)
ab133140
(Active human NEK5 protein fragment)
ab133146
(Active human NEK1 protein fragment)
ab139615
(Active human STK36 protein fragment)
ab140807
(Active human ROR1 protein fragment)
ab151882
(Human Smad3 full length protein)
ab155812
(Active ERK2 full length protein)
ab174066
(Active human LIMK1 protein fragment)
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.
Biological function summary
MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.
Pathways
MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.
MBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.
