Description
Key facts
Species or organism:Human,
Form:LiquidSee storage information
Product details:
ab94146 is a 293T cell transfected lysate in which Human SH2B has been transiently over-expressed using a pCMV-SH2B plasmid. The lysate is provided in 1 x Sample Buffer.
Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH2B1 also known as SH2B adaptor protein 1 or PSM is an adaptor protein that plays roles in cellular signaling pathways. It weighs approximately 80 kDa and is expressed in various tissues including the brain liver and muscle. This protein contains an SH2 domain PH domain and a proline-rich region which enable it to bind to receptors and other signaling proteins. SH2B1 interacts with cell surface receptors activated by growth factors and hormones modulating downstream cellular responses and signal transduction.
Biological function summary
This adaptor protein regulates processes related to energy homeostasis body weight and insulin sensitivity. SH2B1 forms part of a signaling complex that interacts with several tyrosine kinase receptors including the growth hormone receptor and insulin receptor. By binding to these receptors SH2B1 enhances their kinase activity thereby promoting cell growth differentiation and metabolic regulation. Its role is critical in maintaining normal metabolic processes and preventing metabolic disorders.
Pathways
The protein SH2B1 serves integral functions in the insulin signaling pathway and the JAK-STAT pathway. In the insulin signaling pathway SH2B1 facilitates interactions with the insulin receptor which amplifies the signaling cascade necessary for glucose uptake and metabolism. SH2B1 also plays a role in the JAK-STAT pathway by interacting with growth hormone receptors which influences cell proliferation and immune responses. In these pathways SH2B1 interacts with other proteins such as STAT5 and IRS1 which are essential for transmitting signals downstream.
SH2B1 links to obesity and type 2 diabetes both of which involve dysregulation of energy balance and insulin sensitivity. Mutations and alterations in SH2B1 can disrupt normal signaling in pathways resulting in increased risk and manifestation of these metabolic disorders. The protein also links to leptin another protein involved in appetite regulation and energy expenditure. Researchers continue to study the precise mechanisms of SH2B1 in these disease contexts to uncover therapeutic targets and interventions.
