Description
Key facts
Species or organism:Human,
Form:LiquidSee storage information
Product details:
ab94237 is a 293T cell transfected lysate in which Human PACSIN1 has been transiently over-expressed using a pCMV-PACSIN1 plasmid. The lysate is provided in 1 x Sample Buffer.
Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PACSIN1 also known as Syndapin I is a protein that plays a role in membrane trafficking and cytoskeleton organization. It has an alternative name Syndapin I and its molecular mass is approximately 50 kDa. This protein is expressed in the brain particularly in the neuronal tissues where it associates with membranes and interacts with other proteins to regulate endocytosis. Through its F-BAR domain PACSIN1 senses membrane curvature and participates in membrane tubulation processes.
Biological function summary
PACSIN1 contributes to neuronal function by being a component of endocytic and cytoskeletal complexes. It interacts with dynamin and synaptojanin-1 facilitating the assembly of these complexes upon curved membranes. This interaction promotes synaptic vesicle recycling which is critical for efficient neurotransmitter release and synaptic transmission. PACSIN1 is an important part of the vesicle trafficking machinery in neurons directly affecting the dynamics of synapses and overall neuronal communication.
Pathways
PACSIN1 is integrated into the synaptic vesicle cycle and the actin cytoskeleton remodeling pathway. It collaborates with proteins like dynamin I and actin to regulate endocytosis and membrane shaping during synaptic vesicle recycling. These pathways underpin the synaptic vesicle cycle's efficiency and the maintenance of the actin cytoskeleton structure. PACSIN1's interaction with dynamin I demonstrates its significant role in modulating endocytosis speed and efficacy.
PACSIN1 has associations with neural complications like epilepsy and Parkinson's disease. It interacts with synaptic proteins such as synaptojanin-1 whose dysregulation can lead to synaptic dysfunction contributing to these disorders. Impaired PACSIN1 function could disrupt normal synaptic activity leading to neurodegenerative symptoms observed in these diseases. Understanding its role can provide insights into potential therapeutic targets for neurological conditions.
