Description
Key facts
Species or organism:Human,
Form:LiquidSee storage information
Product details:
ab94300 is a 293T cell transfected lysate in which Human ING1 has been transiently over-expressed using a pCMV-ING1 plasmid. The lysate is provided in 1X Sample Buffer.
Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target ING1 also known as Inhibitor of Growth Protein 1 is a tumor suppressor protein with a mass of approximately 33 kDa. It functions mechanically by interacting with chromatin and transcriptional machinery to regulate cell growth apoptosis and DNA repair. ING1 localizes both in the nucleus and cytoplasm showing expression in various tissues but particularly in those with high proliferation rates.
Biological function summary
As part of the chromatin remodeling complex ING1 contributes to the regulation of gene expression by promoting histone acetylation. It affects the cellular response to stress and helps maintain genomic stability. Through interactions with other proteins in the complex ING1 influences cell cycle checkpoints and can induce apoptosis when DNA damage is irreparable.
Pathways
Several important cellular signaling cascades involve ING1. Notably it plays a role in the p53 signaling pathway where it collaborates with the tumor protein p53 to enhance transcriptional activation of downstream genes associated with growth arrest and apoptosis. Additionally ING1 participates in the PI3K/AKT pathway influencing cell survival and metabolism by modulating PI3K-mediated phosphorylation events.
Studies indicate that ING1 has significant links to cancer such as breast and colorectal cancer. Loss or mutation of ING1 disrupts its tumor suppressive functions leading to unchecked cellular proliferation. Moreover its interaction with the protein TP53 highlights its relevance in tumorigenesis as disruptions can impair p53-mediated tumor suppressive pathways further contributing to cancer development.
