Cytiva, 17526904, MabSelect Xtra, 5 L

Name: MabSelect Xtra, 5 L
Brand: Cytiva
SKU: 17526904

Catalog Number: 17526904

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Category

Recombinant Antibodies

Pack Size5 L

TagsChromatography resins Chromatography products Affinity antibody resin

CollectionsCytiva Chromatography Columns, Resins & Lab Glassware Cytiva Protein Analysis Equipment & Supplies Collection

Description

MabSelect Xtra, with extra high dynamic binding capacity, is a protein A resin developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.
Higher dynamic binding capacity than currently available Protein A chromatography resins.
Improved process economics through reduced raw materials costs and/or reduced number of cycles.
High purity capture due to high ligand selectivity and matrix hydrophilicity.
Slightly lower pressure/flow properties compared to MabSelect SuRe and MabSelect.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
Increased porosity
MabSelect Xtra has the same recombinant Protein A ligand as MabSelect but is based on a high-flow agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography resins.
In addition, MabSelect Xtra has a higher capacity for many Fc-fusion proteins.
Lower costs
Compared with he other protein A resins, MabSelect Xtra resin provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.
Prepacked columns and other formats
MabSelect Xtra is available in the following formats:
Process development scale – prepacked
PreDictor MabSelect Xtra filter plates – 96-well plates for high-throughput screening or process development.
PreDictor RoboColumn MabSelect Xtra – minitiaturized column format for high throughput process development
HiScreen MabSelect Xtra columns – optimized for method and process development.
Lab/research scale – prepacked for manual purification
HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.
Lab/research scale – prepacked for automated purification and analysis
HiTrap MabSelect Xtra columns – for easy use with a syringe, peristaltic pump, or chromatography system.
Learn about prepacked HiScreen MabSelect Xtra , HiTrap MabSelect Xtra , ReadyToProcess MabSelect Xtra columns , PreDictor MabSelect Xtra or PreDictor Robocolumns MabSelect Xtra

Specifications

General

Chromatography technique	Antibody affinity chromatography
Binding Capacity/ml Chromatography Medium	Approx. 40 mg humanlgG/mL at 2.4 min residence time
BioProcess resin	Yes
Certificate of Analysis	Yes
Ligand	Recombinant protein A (E.coli)
Ligand Coupling Method	Epoxy activation
Matrix	Highly cross-linked agarose
Particle size, d 50V	~75 µm
Pressure/Flow Specification	< 300 cm/h, < 200 kPa, BPG 300, bed height 20 cm
Storage	2 to 8°C, 20% Ethanol
pH stability, CIP	2–12
pH stability, operational	3–10

FAQs

Question: What purification step is MabSelect Xtra used for?

Answer:Protein A affinity capture of compatible monoclonal antibodies and other Fc-containing targets.

Question: Is the 5 L product a prepacked chromatography column?

Answer:No. It is a 5 L bulk resin pack for filling a suitable chromatography column.

Question: How is antibody eluted from protein A resin?

Answer:A validated change in elution conditions, commonly a controlled acidic elution, releases the antibody from the ligand.

Application Note

MabSelect Xtra Protein A Chromatography Resin is an affinity medium designed for capture purification of monoclonal antibodies from clarified bioprocess feedstocks. Its immobilized protein A ligand binds the Fc region of compatible immunoglobulins, enabling selective recovery of antibodies during a capture chromatography step. The resin is designed for high dynamic binding capacity and helps process concentrated antibody feeds while reducing the number of cycles required for a given batch. This 5 L bulk pack supports column packing, scale-up and process development rather than representing a prepacked cartridge. Establish operating conditions with a suitable equilibration and loading buffer, then optimize washing and elution to control host-cell proteins and other impurities. Monitor pressure, flow and recovery during use, especially after repeated cleaning cycles. Product quality also depends on feedstock preparation, residence time and column packing consistency. Evaluate ligand compatibility, cleaning chemistry and leachate requirements within the process validation plan. The resin is intended for affinity capture and is not a size-exclusion or ion-exchange medium.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

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