Cytiva, 17542015, HiScreen™ MabSelect™ VL

Built for a diversifying pipeline As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1. Redesigned protein L ligand MabSelect™ VL protein L resin showed a two-fold increase in binding capacity compared to our Capto™ L chromatography resin . This higher capacity provides productivity advantages in research and biomanufacturing. The MabSelect™ VL protein L resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand. HiScreen™ columns are convenient for method optimization and parameter screening enabled by the 10 cm bed height for efficient chromatography process development. MabSelect™ VL protein L resin is also available in 1 mL and 5 mL HiTrap™ prepacked columns , bulk resins in different pack sizes , PreDictor™ RoboColumn® minicolumns , and ReadyToProcess™ columns for purifying protein as well as screening and process evaluation. Contact your Cytiva sales representative for more information. Learn more about capture of bispecific antibodies and removal of product-related impurities using MabSelect™ VL resin.