Cytiva, 17546802, Capto SP ImpRes, 100 mL

Name: Capto SP ImpRes, 100 mL
Brand: Cytiva
SKU: 17546802

A strong cation exchange resin for reliable intermediate purification and polishing steps in a commercial setting.

Catalog Number: 17546802

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Category

Ion Exchange Resins

Pack Size100 mL

TagsChromatography resins Ion exchange resins Chromatography products resin

CollectionsCytiva Chromatography Columns, Resins & Lab Glassware Cytiva Protein Analysis Equipment & Supplies Collection

Description

With a high binding capacity and small bead size, Capto™ SP ImpRes strong cation exchanger is a good choice for reliable and robust polishing steps in industrial purification.
High-resolution intermediate purification and polishing resin based on the well-established Capto™ platform with traditional ligands. Smaller particle size compared with Capto™ S.
Flexible process design due to large operational window of flow rates and bed heights.
High throughput purifications easy to optimize and scale-up.
Higher manufacturing productivity enables improved process economy.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support
Designed for large feed volumes
Capto™ SP ImpRes is a strong cation exchanger for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules. This chromatography resin is part of an expanded high-resolution platform based on the high-flow agarose Capto™ product line.
By combining the high-flow characteristics of Capto™ resin with a small particle size, Capto™ SP ImpRes delivers excellent pressure-flow properties with impressive resolution. The ability to run at higher flow rates and higher bed heights also increases flexibility in process design.
Suits large-scale purification processes
Capto™ SP ImpRes is a BioProcess™ chromatography resin developed for large-scale purification of biopharmaceutical proteins. Based on the well-established Capto™ base matrix and with traditional ionic group ligands, it provides many opportunities for improved productivity and straightforward process development.
Prepacked columns and other formats
Capto™ SP ImpRes resin is available in the following formats:
Process development scale: prepacked
PreDictor™ filter plates , 96-well plates for high-throughput screening or process development.
PreDictor™ RoboColumn™ units, miniaturized columns for high-throughput process development.
HiScreen™ columns , optimized for method and process development.
Validation columns , scale-down columns for robust and reproducible process validation and process development (Tricorn™ format)
f (x) columns , precalibrated chromatography column for fast and accurate mechanistic modeling during downstream process development.
Lab scale: prepacked for manual purification
HiTrap™ columns , for easy use with a syringe, peristaltic pump, or chromatography system.
Lab scale: prepacked for automated purification and analysis
HiTrap™ columns , for easy use with a syringe, peristaltic pump, or chromatography system.
Process characterization: resin kits
Process Characterization Kit , designed for studying the potential impact that resin ligand density might have on the process outcome.
Process-scale purification: prepacked
ReadyToProcess™ columns , 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.

Specifications

General

Chromatography technique	Ion Exchange Chromatography
Avoid Using	Oxidizing agents, cationic detergents
Binding Capacity/ml Chromatography Medium	> 70 mg lysozyme, > 95 mg BSA
BioProcess resin	Yes
Certificate of Analysis	Yes
Chemical stability	Commonly used aqueous buffers, 1 M NaOH, 8 M urea, 6 M guanidine hydrochloride, 30% isopropanol and 70 % ethanol
Ion Exchanger Type	Strong cation exchanger
Ionic Capacity	0.13-0.16 mmol H + /ml medium
Ligand	Sulfopropyl group
Matrix	High-flow agarose
Particle Size	36-44 μm (d 50V )
Pressure/Flow Specification	300 kPa at min. 220 cm/h, 1 m diameter column, 20 cm bed height
Storage	4 to 30°C, 20% Ethanol + 0.2 M Sodium Acetate
pH stability, CIP	3–14
pH stability, operational	4–12

FAQs

Question: Is Capto SP ImpRes an anion exchanger?

Answer:No. It is a strong cation exchanger with sulfopropyl functional groups.

Question: What is the typical particle size?

Answer:The high-resolution agarose beads have an approximate average particle size of 40 µm.

Question: Where does it fit in purification?

Answer:It is used mainly for intermediate purification and polishing where close charge-based separation matters.

Application Note

Capto SP ImpRes is a strong cation exchange chromatography resin designed for high-resolution protein purification at intermediate and polishing stages. This 100 mL presentation supports laboratory-scale preparative work, evaluation of product-related variants and method transfer after initial screening. Its sulfopropyl ligand is immobilized on a high-flow agarose matrix with particles approximately 40 µm in diameter. The smaller bead size supports sharper separation of closely related charged species than a coarser capture-oriented resin, while column packing and operating pressure still influence performance. Antibodies and other proteins can be resolved by controlling sample conductivity, binding pH and salt-gradient shape. The resin is particularly useful when the objective is to reduce charge variants, process impurities or aggregates with different retention characteristics. Optimize loading and elution using measured chromatograms rather than assuming all proteins share the same binding profile. Supplied as bulk resin for packing, not as a membrane adsorber.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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