Cytiva, 17547002, Capto Q ImpRes, 100 mL

Name: Capto Q ImpRes, 100 mL
Brand: Cytiva
SKU: 17547002

Catalog Number: 17547002

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Category

Process-Scale Chromatography Resins

Pack Size100 mL

TagsChromatography resins Ion exchange resins Chromatography products resin

CollectionsCytiva Chromatography Columns, Resins & Lab Glassware Cytiva Protein Analysis Equipment & Supplies Collection

Description

By combining high-flow characteristics of Capto with a small particle size, Capto Q ImpRes delivers high resolution and excellent pressure-flow properties.
High-resolution intermediate purification and polishing based on the well-established Capto platform with traditional ligands.
Flexible process design due to large operational window of flow rates and bed heights.
High-throughput purifications easy to optimize and scale up.
Higher manufacturing productivity enables improved process economy.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
High resolution and process design flexibilty
Capto Q ImpRes is a strong anion exchanger for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules. This chromatography resin is part of an expanded high-resolution platform based on the high-flow agarose Capto product line.
The ability to run at higher flow rates and higher bed heights also increases flexibility in process design.
Productivity and process development
Capto Q ImpRes is a bioprocess chromatography resin developed for large-scale purification of biopharmaceutical proteins. Based on the well-established Capto base matrix and with traditional ionic group ligands, it provides many opportunities for improved productivity and straightforward process development.
Prepacked columns and other formats
Capto Q ImpRes is available in the following formats:
Process development scale – prepacked
PreDictor Capto Q ImpRes filter plates – 96-well plates for high-throughput screening or process development.
PreDictor Capto Q ImpRes RoboColumn units – miniaturized columns for high-throughput process development.
HiScreen Capto Q ImpRes columns – optimized for method and process development.
f (x) column , prepacked and precharacterized chromatography column for fast and accurate mechanistic modeling.
Lab/research scale – prepacked for manual purification
HiTrap Capto Q ImpRes columns – for easy use with a syringe, peristaltic pump, or chromatography system.
Lab/research scale – prepacked for automated purification and analysis
HiTrap Capto Q ImpRes columns – for easy use with a syringe, peristaltic pump, or chromatography system.
Process-scale purification – prepacked
ReadyToProcess Capto Q ImpRes columns – 1 L and larger columns for clinical manufacturing that avoid the need for cleaning and cleaning validation.

Specifications

General

Chromatography technique	Ion Exchange Chromatography
Avoid Using	Oxidizing agents, anionic detergents
Binding Capacity/ml Chromatography Medium	> 55 mg BSA, > 48 mg β-lactoglobulin
BioProcess resin	Yes
Certificate of Analysis	Yes
Chemical stability	Commonly used aqueous buffers, 1 M NaOH, 8 M urea, 6 M guanidine hydrochloride, 30% isopropanol and 70 % ethanol
Ionic Capacity	0.15-0.18 mmol Cl - /ml medium
Ligand	Quaternary amine
Matrix	High-flow agarose
Particle Size	36-44 μm (d 50V )
Pressure/Flow Specification	300 kPa at min. 220 cm/h, 1 m diameter column, 20 cm bed height
Storage	4 to 30°C, 20% Ethanol
pH stability, CIP	2–14
pH stability, operational	2–12

FAQs

Question: Is Capto Q ImpRes a weak or strong anion exchanger?

Answer:It is a strong anion exchanger based on quaternary ammonium functionality.

Question: What is the supplied package size?

Answer:The package supplies 100 mL of Capto Q ImpRes bulk chromatography resin for column packing.

Question: Which purification step does it serve?

Answer:High-resolution intermediate purification and polishing of proteins and other biomolecules.

Application Note

Capto™ Q ImpRes is a high-resolution strong anion-exchange resin for intermediate purification and polishing of biomolecules. Its quaternary ammonium functionality retains anion-exchange characteristics over a broad working pH range, while the high-flow agarose matrix and relatively small bead format support sharp separations. The medium is useful where closely related product forms or charged impurities must be resolved without sacrificing preparative throughput. Establish binding conditions by screening buffer pH and conductivity, then develop a salt gradient or step elution that separates the desired product from the impurity profile. Because peak resolution depends on bed height, flow, loading and feed composition, scale-up should preserve the controlling process parameters rather than replicate laboratory flow rates mechanically. Evaluate pressure drop and dynamic binding capacity with representative feed samples. The 100 mL bulk-resin package is suitable for packing a method-development or preparative column. It is distinct from a prepacked HiTrap, HiScreen or ReadyToProcess device.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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