Answer:To organize antibodies into groups using their competitive or noncompetitive binding behavior toward an antigen.
Answer:No. Competition-based binning describes binding relationships; it does not reveal atomic epitope structures.
Answer:One permanent Biacore Insight Epitope Binning software license.
The Biacore Insight Epitope Binning extension adds experimental evaluation tools for grouping antibodies by competition behavior on a target antigen. In an SPR epitope-binning workflow, antibodies are tested in paired or sequential binding arrangements to determine whether one antibody interferes with binding by another. The resulting competition patterns help identify overlapping, adjacent or distinct binding regions without assigning an atomic epitope structure. This extension supports setup and interpretation of binning studies within compatible Biacore Insight software, making it relevant to antibody discovery, therapeutic lead selection and panel diversification. Evaluate assay orientation, ligand density, binding kinetics and regeneration conditions before drawing competition conclusions; steric effects and conformational changes can affect the result. Use replicates and reference measurements to strengthen the analysis. This is a permanent single-license software extension, not a reagent, capture kit or sensor chip. Verify software version and license activation requirements.
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