Merck, 1371590010, DL-Dithiothreitol

Name: DL-Dithiothreitol
Brand: Merck
SKU: 1371590010

Size:10 g, DL-Dithiothreitol, Cleland’s reagent, DTT, threo-1, 4-Dimercapto-2, 3-butanediol, threo-1, 4-Dimercapto-2, 3-butanediol, Cleland’s reagent, EMPROVE® ESSENTIAL

Catalog Number: 1371590010

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Category

Protein Labeling Kits

Pack Size10 g

TagsChemistry & Biochemicals Formulation Protein Stabilizers

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Our SAFC Pharma® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.
M-Clarity Program
As part of our Emprove® Program, our raw materials are offered with Emprove® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.
Application
An excellent reagent for maintaining SH groups in reduced state; quantitatively reduces disulfides. DTT is effective in sample buffers for reducing protein disulfide bonds prior to SDS-PAGE. DTT can also be used for reducing the disulfide bridge of the cross-linker N,N′-bis(acryloyl)cystamine to break apart the matrix of a polyacrylamide gel. DTT is less pungent and is less toxic than 2-mercaptoethanol. Typically, a seven fold lower concentration of DTT (100 mM) is needed than is used for 2-mercaptoethanol (5% v/v, 700 mM).
DTT is an excellent reagent chemical used to reduce disulfide bonds commonly found in bioprocessing. DTT is used in buffer formulations to maintain and stabilize free -SH in applications such as protein based biotherapeutics and enzyme stability.
Packaging
1.37159.0010 / 10 g / Amber glass bottle
1.37159.0100 / 100 g / Amber glass bottle
1.37159.1000 / 1 kg / LDPE bag with outer HDPE drum
1.37159.9010 / 10 kg / LDPE bag with outer HDPE drum
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC Pharma is a registered trademark of Sigma-Aldrich Co. LLC

Specifications

General

EC Index Number	222-468-7
UNSPSC Code	12352200
Beilstein/REAXYS Number	1719757
MDL number	MFCD00004877
SMILES string	O[C@H](CS)[C@H](O)CS
InChI	1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
InChI key	VHJLVAABSRFDPM-QWWZWVQMSA-N
biological source	synthetic
product line	EMPROVE® ESSENTIAL
technique(s)	in vitro transcription (IVT): suitable
mp	41-44 °C (lit.)
application(s)	pharma/biopharma processes
storage temp.	−20°C (−15°C to −25°C)
Quality Level	500

Ordering

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