Merck, 14023AST, Astec® CHIROBIOTIC® TAG Chiral HPLC Column

General description
The removal of three carbohydrate moieties gives CHIROBIOTIC® TAG complementary selectivity to CHIROBIOTIC® T. Resolution is enhanced toward many of the amino acids, α, β, γ and cyclic, and especially sulfur-containing methionine, histidine and cysteine. A number of neutral molecules like the oxazolidinones, hydantoins and diazepines have shown enhanced resolution and, more remarkably, in the single solvents like methanol, ethanol and acetonitrile. Some acidic molecules have also shown increased selectivity.

Bonded phase: Teicoplanin aglycone
Operating pH range: 3.0 - 6.8
Particle diameter: 5, 10 or 16 μm
Pore size: 100 Å

Application

High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This study emphasizes the effectiveness of the Astec® CHIROBIOTIC® TAG Chiral HPLC Column in the enantioseparation of complex cyclic amino acids. The methodology detailed provides profound insights into the chirality aspects of biochemical molecules, which is crucial for the synthesis of novel pharmaceutical agents and the study of biochemical pathways. This research supports analytical chemists in academia focused on developing chiral analytical methods and advancing chemical synthesis (Berkecz et al., 2009).

Other Notes
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Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC