Description
General description
A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 219675).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CFTR
Product does not compete with ATP.
Reversible: yes
Target IC₅₀: 95% inhibition at 50 µM
Target Ki: 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Sonawane, N.D., et al. 2006. FASEB J.20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol.124, 125.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)