Merck, 401478-1MG, IκB Kinase Inactive Control Peptide, Cell-Permeable

General description
An inactive control for IκB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IκB (Ser³²→Ala and Ser³⁶→Ala) fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.
An inactive control for IkB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IkB (Ser³² → Ala and Ser³⁶ → Ala), linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.
Biochem/physiol Actions
Cell permeable: no
Primary Target
An inactive control for IκB Kinase Inhibitor Peptide
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ala-Gly-Leu-Asp-Ala-Met-Lys-Asp-Glu-NH₂
Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO J.14, 2876.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)