Merck, 53886-1MG, Tn Antigen

Name: Tn Antigen
Brand: Merck
SKU: 53886-1MG

Size:1 mg, GalNac-α-1-O-serine, O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine, ≥99.0% (TLC)

Catalog Number: 53886-1MG

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Category

General Purpose Incubators

Pack Size1 mg

TagsProtein Biology Proteins & Enzymes Glycobiology Profiling Tools

CollectionsMerck Proteins & Enzymes: Nucleases, Albumins & High‑Purity Enzymes Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Biochem/physiol Actions
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.

Specifications

General

UNSPSC Code	12352204
PubChem Substance ID	329758013
NACRES	NA.32
Web Name Suffix Override	≥99.0% (TLC), powder or crystals
MDL number	MFCD01863462
SMILES string	CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
InChI	1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChI key	REDMNGDGDYFZRE-WKWISIMFSA-N
assay	≥99.0% (TLC)
form	powder or crystals
storage temp.	−20°C
Quality Level	100

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