Merck, 58221-U, SUPELCOSIL™ LC-CN HPLC Column

Name: SUPELCOSIL™ LC-CN HPLC Column
Brand: Merck
SKU: 58221-U

Size:1 ea, MTO-SUPELCOSIL™ LC-CN 5UM 15CMX4.6MM HPLC COLUMN, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Catalog Number: 58221-U

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Category

Chiral HPLC Columns

Pack Size1 ea

TagsHPLC Columns Analytical Chemistry Analytical Chromatography

CollectionsMerck Analytical Chromatography Products & Lab Supplies Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
The LC-CN phase is often used as a substitute for silica because it offers the advantages of a bonded phase (such as quick equilibration, and less sensitivity to small changes of the water content in the mobile phase). More often, however, the LC-CN column is operated under reversed-phase mobile phase conditions.
Application

Validated Simple HPLC-UV Method for Mycophenolic Acid (MPA) Monitoring in Human Plasma. Internal Standardization: : This study presents a validated HPLC-UV method for monitoring mycophenolic acid in human plasma. The research highlights the necessity and efficiency of internal standardization in achieving accurate measurements. (Kunicki PK et al., 2021).

An Improved HPLC Method for Therapeutic Drug Monitoring of Daunorubicin, Idarubicin, Doxorubicin, Epirubicin, and Their 13-dihydro Metabolites in Human Plasma.: This paper describes an enhanced HPLC method for monitoring therapeutic levels of several chemotherapeutic agents and their metabolites in human plasma, improving the accuracy and reliability of drug monitoring. (Fogli S et al., 1999).

Analysis of Diltiazem and Desacetyldiltiazem in Serum by High-Performance Liquid Chromatography.: This research focuses on an HPLC method for analyzing diltiazem and its primary metabolite in serum, providing a robust tool for clinical pharmacokinetic studies. (Paczkowski D et al., 1995).

High-Performance Liquid Chromatographic Method for the Determination of Eclanamine and Its N-Desmethyl and N,N-Didesmethyl Metabolites in Urine.: The study details a high-performance liquid chromatographic method for determining eclanamine and its metabolites in urine, crucial for pharmacokinetic and toxicological analysis. (Lakings DB et al., 1988).

Other Notes
Discover LiChropur reagents ideal for HPLC or LC-MS analysis
Legal Information
SUPELCOSIL is a trademark of Sigma-Aldrich Co. LLC

Specifications

General

UNSPSC Code	41115700
eCl@ss	32110501
Web Name Suffix Override	L × I.D. 15 cm × 4.6 mm, HPLC Column
Web Name Override	SUPELCOSIL™ LC-CN (5 µm) HPLC Columns
NACRES	SB.52
material	stainless steel column
agency	suitable for USP L10
product line	SUPELCOSIL™
feature	endcapped
packaging	1 ea of
extent of labeling	4% Carbon loading
parameter	≤70 °C temp. range
technique(s)	HPLC: suitable
L × I.D.	15 cm × 4.6 mm
surface area	170 m2/g
surface coverage	surface coverage 3.5 μmol/m2
matrix	silica gel, spherical particle platform
matrix active group	cyano phase
particle size	5 μm
pore size	120 Å
pH range	2-7.5
separation technique	hydrophilic interaction (HILIC)
Quality Level	100

FAQs

Question: What stationary phase does LC-CN contain?

Answer:It uses cyanopropyl-bonded silica, also described as a cyano or CN phase.

Question: What are the physical specifications?

Answer:The analytical column is 150 × 4.6 mm with 5 µm particles.

Question: Can it be used only in reversed-phase mode?

Answer:No. Cyano stationary phases can support suitable normal-phase and reversed-phase methods.

Application Note

Merck Supelco SUPELCOSIL LC-CN is a cyanopropyl-bonded silica analytical HPLC column containing 5 µm particles in a 150 × 4.6 mm configuration. The cyano phase provides polar selectivity and can be used in appropriate normal-phase or reversed-phase methods depending on the mobile phase. Its retention profile is not interchangeable with a standard C18 or amino phase, making the bonded chemistry an important consideration in established method replacement. The 150 mm column length and 4.6 mm internal diameter match a conventional analytical HPLC format. This is a complete LC-CN column rather than a guard cartridge.

Ordering

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