Description
General description
Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells. 18:0 Lyso PA has stearic acid at sn-1 and a hydroxyl group at sn-2 position.
Application
18:0 Lyso PA is suitable for use:
to determine the extraction recovery of LPA at neutral pH and acidic pH by chromatographic method
to use as internal standard to study the role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis
to investigate its effects on clathrin?dependent endocytosis
Biochem/physiol Actions
Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).
Packaging
5 mL Amber Glass Screw Cap Vial (857128P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC