Merck, 927708-250MG, 2,2,11-trimethyl-4-oxo-3,8-dioxa-5,11-diazatetradecan-14-oic acid

Name: 2,2,11-trimethyl-4-oxo-3,8-dioxa-5,11-diazatetradecan-14-oic acid
Brand: Merck
SKU: 927708-250MG

Size:250 mg, ≥95%

Available Catalog Numbers

Catalog Number: 927708-250MG

Pricing

Category

Pack Size250 mg

Description

Application
2,2,11-trimethyl-4-oxo-3,8-dioxa-5,11-diazatetradecan-14-oic acid is a heterobifunctional crosslinker useful for development of PROTAC degraders for targeted protein degradation or other bifunctional molecules in chemical biology. Incorporation of rigidity into the linker region may impact the 3D orientation of the molecules and thus ternary complex formation as well as optimization of drug-like properties. For linkers already conjugated to E3 ligase ligands, please visit our collection of Protein Degrader Building Blocks.
Other Notes
Technology Article: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks Portal

Crosslinkers for Bioconjugation

Specifications

Ordering

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