Merck, 933651-1G, Poly(caprolactone fumarate)

General description
Poly(caprolactone fumarate) (PCLF) is a crosslinkable, biodegradable polymer consisting of poly(caprolactone) (PCL) and unsaturated fumarate repeating units. This derivative of PCL can be crosslinked to form a three-dimensional polymer network or scaffold. PCLF has been widely investigated for tissue engineering, 3D bioprinting, and drug delivery applications due to its biodegradability, biocompatibility and mechanical performance.
Application

• Tissue engineering including bone and nerve regeneration
• 3D bioprinting
• Drug delivery

Poly(caprolactone fumarate) (PCLF) is a macromonomer consisting of poly(caprolactone) and fumarate repeating units. The bio-compatible poly(capralactone) units shows flexibility and fumarate repeat units provide cross linking ability without adding any toxic cross-linkers
Features and Benefits

• Biocompatible
• Crosslinkable via photopolymerization, radical polymerziation, thermal polymereization
• Flexible polymer chain
• Biodegradable via hydrolysis of the ster bonds in both PCL and fumarate segments